The leaves of Croton zambesicus are widely used in African folk medicine as a water decoction to treat hypertension, microbial infections and fever associated with malaria. Cytotoxic trachylobane and pimarane diterpenes have been isolated from a dichloromethane extract of the leaves. In order to check whether these compounds are present in the essential oil, we have analysed its composition by GC-FID and GC–MS. The major constituents of the oil are caryophyllene oxide (19.5%), β-caryophyllene (10.8%), α-copaene (6.3%), linalool (6.1%) and β-pinene (5.2%). Only the less polar diterpenes are present in the oil: ent-trachyloban-3-one (3.0%), ent-trachyloban-3β -ol (0.5%), isopimara-7, 15- dien-3β -ol (1.0%), ent-trachylobane (0.7%), sandaracopimaradiene (0.4%) and kaurene (2.1%)

Analysis of the essential oil from leaves of Croton zambesicus Muell. Arg. growing in Benin

FLAMINI, GUIDO;MORELLI, IVANO;
2006-01-01

Abstract

The leaves of Croton zambesicus are widely used in African folk medicine as a water decoction to treat hypertension, microbial infections and fever associated with malaria. Cytotoxic trachylobane and pimarane diterpenes have been isolated from a dichloromethane extract of the leaves. In order to check whether these compounds are present in the essential oil, we have analysed its composition by GC-FID and GC–MS. The major constituents of the oil are caryophyllene oxide (19.5%), β-caryophyllene (10.8%), α-copaene (6.3%), linalool (6.1%) and β-pinene (5.2%). Only the less polar diterpenes are present in the oil: ent-trachyloban-3-one (3.0%), ent-trachyloban-3β -ol (0.5%), isopimara-7, 15- dien-3β -ol (1.0%), ent-trachylobane (0.7%), sandaracopimaradiene (0.4%) and kaurene (2.1%)
2006
Block, S; Flamini, Guido; Brkic, D; Morelli, Ivano; QUETIN LECLERQ, J.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/101035
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