Cardiovascular disease (CVD), here referring to atherothrombotic CVD, is the main cause of death worldwide. Although epidemiologic studies have identified several modifiable environmental risk factors involved in its pathophysiology, most factors also have a genetic basis. Dietary components are a main environmental factor interacting with our genome to produce a disease phenotype and affect most of the risk factors for CVD. Therefore, understanding cardiovascular nutrigenetics can lead to a better understanding of the individual response to dietary interventions; it holds the promise to tailor and personalize such interventions. This chapter summarizes the main examples of diet–gene interaction favoring CVD. These include polymorphisms of apolipoprotein E (APOE), fatty acid desaturase (FADS), 5-lipoxygenase (5-LO), peroxisome proliferator-activated receptors (PPARs), and methylenetetrahydrofolate reductase (MTHFR).
The Nutrigenetics of Cardiovascular Disease
Rosalinda Madonna;Raffaele De Caterina
2019-01-01
Abstract
Cardiovascular disease (CVD), here referring to atherothrombotic CVD, is the main cause of death worldwide. Although epidemiologic studies have identified several modifiable environmental risk factors involved in its pathophysiology, most factors also have a genetic basis. Dietary components are a main environmental factor interacting with our genome to produce a disease phenotype and affect most of the risk factors for CVD. Therefore, understanding cardiovascular nutrigenetics can lead to a better understanding of the individual response to dietary interventions; it holds the promise to tailor and personalize such interventions. This chapter summarizes the main examples of diet–gene interaction favoring CVD. These include polymorphisms of apolipoprotein E (APOE), fatty acid desaturase (FADS), 5-lipoxygenase (5-LO), peroxisome proliferator-activated receptors (PPARs), and methylenetetrahydrofolate reductase (MTHFR).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
