Left ventricular remodeling after myocardial infarction has been identified as a predictor of adverse outcome and as a relevant therapeutic target. It has been shown that upregulation of the renin-angiotensin-aldosterone system (RAAS)* has an important role in the pathogenesis of cardiac remodeling. In this paper we summarize evidence on the role of the RAAS in the development of left ventricular remodeling and review major trials based on the addition of an RAAS inhibitor to standard therapy in the post myocardial infarction setting to prevent remodeling and improve outcome.
Role of RAAS inhibition in preventing left ventricular remodeling in patients post myocardial infarction
Morrone D.
;Marzilli M.
2010-01-01
Abstract
Left ventricular remodeling after myocardial infarction has been identified as a predictor of adverse outcome and as a relevant therapeutic target. It has been shown that upregulation of the renin-angiotensin-aldosterone system (RAAS)* has an important role in the pathogenesis of cardiac remodeling. In this paper we summarize evidence on the role of the RAAS in the development of left ventricular remodeling and review major trials based on the addition of an RAAS inhibitor to standard therapy in the post myocardial infarction setting to prevent remodeling and improve outcome.File in questo prodotto:
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