This study evaluated the effects of barbexaclone on the frequency of seizures in a group of 40 epileptics, previously treated with phenobarbital. The effect of barbexaclone compared with phenobarbital on vigilance was assessed by means of the Digit Symbol Substitution Test, visuomotor reaction times in lateralized vision, and a subjective scale. After four and eight months of barbexaclone therapy, serum phenobarbital levels were substantially unchanged, while the frequency of seizures was reduced by at least half in 25% of the patients examined. In the level of vigilance, patients reported less drowsiness, confirmed by improvements in performance of the Digit Symbol Substitution Test. No specific correlation with reaction times was observed, however
COMPARISON OF THE EFFECTS OF BARBEXACLONE AND PHENOBARBITAL ON EPILEPTIC PATIENTS
BONANNI, ENRICASecondo
;BONUCCELLI, UBALDOPenultimo
;
1987-01-01
Abstract
This study evaluated the effects of barbexaclone on the frequency of seizures in a group of 40 epileptics, previously treated with phenobarbital. The effect of barbexaclone compared with phenobarbital on vigilance was assessed by means of the Digit Symbol Substitution Test, visuomotor reaction times in lateralized vision, and a subjective scale. After four and eight months of barbexaclone therapy, serum phenobarbital levels were substantially unchanged, while the frequency of seizures was reduced by at least half in 25% of the patients examined. In the level of vigilance, patients reported less drowsiness, confirmed by improvements in performance of the Digit Symbol Substitution Test. No specific correlation with reaction times was observed, howeverI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
