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EnglishRecent studies of the lamprey spinal cord have shown that hemisegmental preparations can display rhythmic activity in response to a constant input drive. This activity is believed to be generated by a network of recurrently connected excitatory interneurons. A recent study found and characterized self-sustaining rhythmic activity—locomotor bouts—after brief electrical stimulation of hemisegmental preparations. The mechanisms behind the bouts are still unclear. We have developed a computational model of the hemisegmental network. The model addresses the possible involvement of NMDA, AMPA, acetylcholine, and metabotropic glutamate receptors as well as axonal delays in locomotor bouts.
| Autori interni: | |
| Autori: | HUSS M; CANGIANO L; HELLGREN KOTALESKI J |
| Titolo: | Modelling self-sustained rhythmic activity in lamprey hemisegmental networks |
| Anno del prodotto: | 2006 |
| Digital Object Identifier (DOI): | 10.1016/j.neucom.2005.12.053 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/104529
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