Recent studies of the lamprey spinal cord have shown that hemisegmental preparations can display rhythmic activity in response to a constant input drive. This activity is believed to be generated by a network of recurrently connected excitatory interneurons. A recent study found and characterized self-sustaining rhythmic activity—locomotor bouts—after brief electrical stimulation of hemisegmental preparations. The mechanisms behind the bouts are still unclear. We have developed a computational model of the hemisegmental network. The model addresses the possible involvement of NMDA, AMPA, acetylcholine, and metabotropic glutamate receptors as well as axonal delays in locomotor bouts.
|Autori:||HUSS M; CANGIANO L; HELLGREN KOTALESKI J|
|Titolo:||Modelling self-sustained rhythmic activity in lamprey hemisegmental networks|
|Anno del prodotto:||2006|
|Digital Object Identifier (DOI):||10.1016/j.neucom.2005.12.053|
|Appare nelle tipologie:||1.1 Articolo in rivista|