It is well known that flavanones have beneficial health effects. Eriodictyol-7-rutinoside, also called eriocitrin, is a flavanone with many pos. effects. Like many of these compds., low water soly., stability and shelf life are major issues. Many studies have focused on improving these aspects. Towards this goal, β-cyclodextrin and its derivs. are interesting candidates. These compds. are characterized by a hydrophobic central cavity that usually enhances ligand soly. in aq. solns., affecting the chem. characteristics of the encapsulated ligand. Recently, eriocitrin/hydroxypropyl-β-cyclodextrin complex with advanced properties has been reported. Herein, computational approaches were combined with NMR spectroscopy to characterize the eriocitrin/β-cyclodextrin complex and compare it with that of eriocitrin/hydroxypropyl-β-cyclodextrin.
Interaction of natural flavonoid eriocitrin with β-cyclodextrin and hydroxypropyl-β-cyclodextrin: an {NMR} and molecular dynamics investigation
Andrea CesariPrimo
;Gloria Uccello BarrettaSecondo
;Federica Balzano
Ultimo
2020-01-01
Abstract
It is well known that flavanones have beneficial health effects. Eriodictyol-7-rutinoside, also called eriocitrin, is a flavanone with many pos. effects. Like many of these compds., low water soly., stability and shelf life are major issues. Many studies have focused on improving these aspects. Towards this goal, β-cyclodextrin and its derivs. are interesting candidates. These compds. are characterized by a hydrophobic central cavity that usually enhances ligand soly. in aq. solns., affecting the chem. characteristics of the encapsulated ligand. Recently, eriocitrin/hydroxypropyl-β-cyclodextrin complex with advanced properties has been reported. Herein, computational approaches were combined with NMR spectroscopy to characterize the eriocitrin/β-cyclodextrin complex and compare it with that of eriocitrin/hydroxypropyl-β-cyclodextrin.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.