The peripheral benzodiazepine receptor (PBR) is a ubiquitary protein which is mainly localized in mitochondria, and plays a pivotal role in the cell homeostasis. Previous studies had evidenced alterations in PBR expression levels during acute or chronic stress states and in many mental diseases. In mitochondrial membranes of lymphocytes isolated from PTSD or CG patients the PBR density has been found decreased with respect to healthy controls (t test: p<0,05). To assess the relationship between disease-induced PBR levels and the symptoms of PTSD and CG, we evaluated correlations between PBR density and the psychiatric scale scores obtained by patients.
Correlation between lymphocytic peripheral benzodiazepine receptor levels and psychiatric scale scorse in post-traumatic stress disorder and traumatic grief
DELL'OSSO, LILIANA;DA POZZO, ELEONORA;CARMASSI, CLAUDIA;TRINCAVELLI, MARIA LETIZIA;MARTINI, CLAUDIA
2006-01-01
Abstract
The peripheral benzodiazepine receptor (PBR) is a ubiquitary protein which is mainly localized in mitochondria, and plays a pivotal role in the cell homeostasis. Previous studies had evidenced alterations in PBR expression levels during acute or chronic stress states and in many mental diseases. In mitochondrial membranes of lymphocytes isolated from PTSD or CG patients the PBR density has been found decreased with respect to healthy controls (t test: p<0,05). To assess the relationship between disease-induced PBR levels and the symptoms of PTSD and CG, we evaluated correlations between PBR density and the psychiatric scale scores obtained by patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
