Objective: To describe the possibility that dopamine infusion can prevent early diagnosis of congenital hypothyroidism. Design: Case report. Setting: Medical neonatal intensive care unit of a tertiary academic medical center. Patients: We report four preterm newborns affected by transient primary congenital hypothyroidism who showed low serum thyroxine and normal thyroid-stimulating hormone concentrations on primary screening performed during treatment with dopamine. Interventions: Thyroid reevaluation screening after dopamine discontinuation. Measurements and Main Results: Thyroid reevaluation showed elevated thyroid-stimulating hormone levels. Conclusion: We emphasize that dopamine capacity to suppress thyroid-stimulating hormone could prevent early diagnosis of congenital hypothyroidism. We suggest all newborns to be tested simultaneously for thyroid-stimulating hormone and thyroxine values at primary screening. A reevaluation of thyroid hormones after dopamine discontinuation is advisable in patients treated with dopamine. Copyright © 2006 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
Dopamine infusion: A possible cause of undiagnosed congenital hypothyroidism in preterm infants
Filippi L.;
2006-01-01
Abstract
Objective: To describe the possibility that dopamine infusion can prevent early diagnosis of congenital hypothyroidism. Design: Case report. Setting: Medical neonatal intensive care unit of a tertiary academic medical center. Patients: We report four preterm newborns affected by transient primary congenital hypothyroidism who showed low serum thyroxine and normal thyroid-stimulating hormone concentrations on primary screening performed during treatment with dopamine. Interventions: Thyroid reevaluation screening after dopamine discontinuation. Measurements and Main Results: Thyroid reevaluation showed elevated thyroid-stimulating hormone levels. Conclusion: We emphasize that dopamine capacity to suppress thyroid-stimulating hormone could prevent early diagnosis of congenital hypothyroidism. We suggest all newborns to be tested simultaneously for thyroid-stimulating hormone and thyroxine values at primary screening. A reevaluation of thyroid hormones after dopamine discontinuation is advisable in patients treated with dopamine. Copyright © 2006 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.