This chapter mainly focuses on the role played by membranes and red-ox active and red-ox inert metal ions in triggering the pathogenic mechanisms of Protein Conformational Diseases. In addition, firstly, the basic rules governing lipid-peptide interactions were concisely reviewed; secondly, the effects of several membrane-mimicking environments on the conformational preferences of biologically active peptides were discussed.
Environmental effects on conformational diseases. Reactive oxygen species and membrane interactions with prion, amylin and their peptide fragments
LA MENDOLA, DIEGO;
2006-01-01
Abstract
This chapter mainly focuses on the role played by membranes and red-ox active and red-ox inert metal ions in triggering the pathogenic mechanisms of Protein Conformational Diseases. In addition, firstly, the basic rules governing lipid-peptide interactions were concisely reviewed; secondly, the effects of several membrane-mimicking environments on the conformational preferences of biologically active peptides were discussed.File in questo prodotto:
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