Abstract We report on two cases of patients who developed diabetes insipidus (DI) before acute erythroleukaemia (EL). A brain MRI showed an empty sella turcica in one case and hypothalamo-hypophyseal peduncle damage in the second case. Reduced levels of TGF-β1 and Vitamin D3, with associated EVI-1 over-expression and karyotypic abnormalities were documented. These two cases show specific chromosomal/molecular alterations in EL with DI. The hypothesis of pituitary involvement in erythroleukemogenesis is discussed. Keywords • Erythroleukaemia; • Diabetes insipidus; • Empty sella; • TGF-β1; • EVI-1
Erythroleukaemia, diabetes insipidus and hypophyseal damage. Two case reports
ROVIGATTI, UGO
2007-01-01
Abstract
Abstract We report on two cases of patients who developed diabetes insipidus (DI) before acute erythroleukaemia (EL). A brain MRI showed an empty sella turcica in one case and hypothalamo-hypophyseal peduncle damage in the second case. Reduced levels of TGF-β1 and Vitamin D3, with associated EVI-1 over-expression and karyotypic abnormalities were documented. These two cases show specific chromosomal/molecular alterations in EL with DI. The hypothesis of pituitary involvement in erythroleukemogenesis is discussed. Keywords • Erythroleukaemia; • Diabetes insipidus; • Empty sella; • TGF-β1; • EVI-1File in questo prodotto:
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