In order to investigate the role of peripheral GABA-B receptors, the effects of the putative GABA-B agonist baclofen on immunoreactive gastrin release from an isolated vascularly perfused rat stomach preparation were examined. The vascular infusion of baclofen at graded concentrations induced a dose-dependent increase in gastrin release; this was unaffected by the GABA-B antagonist delta-aminovaleric acid, but was fully prevented by the selective GABA-A antagonist bicuculline as well as by atropine or tetrodotoxin. These results suggest that the stimulant effects of baclofen are mediated by nervous cholinergic structures associated with GABA-A receptors, and indicate that this GABA-B agonist must be regarded as a partial agonist of peripheral GABA-A receptors.
|Autori:||Del Tacca M.; BLANDIZZI C; Bernardini M.C.; Martelli F.; Della Longa A.|
|Titolo:||GABA-A-mediated gastrin release induced by baclofen in the isolated vascularly perfused rat stomach|
|Anno del prodotto:||1989|
|Digital Object Identifier (DOI):||10.1007/BF01974572|
|Appare nelle tipologie:||1.1 Articolo in rivista|