The possibility to form new C–B bonds with aziridines using diboron derivatives continues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being a bioisostere of β-aminoacids. We now report experimental and computational data that allows the individuation of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B2pin2) in a regioselective nucleophilic addition reaction under copper catalysis.
Copper-Catalyzed Ring-Opening Reactions of Alkyl Aziridines with B2pin2: Experimental and Computational Studies
Favero, Lucilla
Primo
;Comparini, Lucrezia Margherita;Di Bussolo, Valeria;Di Pietro, SebastianoPenultimo
;Pineschi, Mauro
Ultimo
2021-01-01
Abstract
The possibility to form new C–B bonds with aziridines using diboron derivatives continues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being a bioisostere of β-aminoacids. We now report experimental and computational data that allows the individuation of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B2pin2) in a regioselective nucleophilic addition reaction under copper catalysis.File in questo prodotto:
File | Dimensione | Formato | |
---|---|---|---|
2021 - Boro Aziridine Molecules.pdf
accesso aperto
Descrizione: Final Version
Tipologia:
Versione finale editoriale
Licenza:
Creative commons
Dimensione
5.86 MB
Formato
Adobe PDF
|
5.86 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.