Ageing is a major risk factor for cardiovascular disease.1 With the occurrence of cellular ageing, favoured by the exposure to cardiovascular risk factors, comorbidities, and various stressors, such as bouts of ischaemia and/or ischaemia–reperfusion, the function and cross-talk of cardiac stromal cells (CSCs) and vascular and parenchymal cells, including cardiomyocytes, is diminished, hampering their cardioprotective potential.2 Ageing is also an important determinant of metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome.1 Older men and women tend to have worsened glycaemia-related parameters, i.e. fasting and 2-h plasma glucose and HbA1c concentrations, than their younger counterparts.
Vascular rejuvenation: A new therapeutic target?
Madonna R.
Primo
Conceptualization
2021-01-01
Abstract
Ageing is a major risk factor for cardiovascular disease.1 With the occurrence of cellular ageing, favoured by the exposure to cardiovascular risk factors, comorbidities, and various stressors, such as bouts of ischaemia and/or ischaemia–reperfusion, the function and cross-talk of cardiac stromal cells (CSCs) and vascular and parenchymal cells, including cardiomyocytes, is diminished, hampering their cardioprotective potential.2 Ageing is also an important determinant of metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome.1 Older men and women tend to have worsened glycaemia-related parameters, i.e. fasting and 2-h plasma glucose and HbA1c concentrations, than their younger counterparts.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
