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EnglishThe absolute configuration of a potent new antitumor dihydroxanthenone, globosuxanthone A (1), active against human solid tumor cell lines and isolated by Gunatilaka et al. from Chaetomium globosum Ames[1] and in this study from the endophytic fungus Microdiplodia sp., was established by a new methodology. In this new approach, the Cartesian coordinates of the X-ray data serve as input geometry for quantum mechanical calculation of the theoretical CD spectrum. Comparison with the solid-state CD spectrum gives a very good match, since the calculated and the experimentally acquired data are derived from the very same single conformation.
| Autori interni: | ||
| Autori: | HUSSAIN H; KROHN K; FLOERKE U; SCHULZ B; DRAEGER S; PESCITELLI G; ANTUS S; KURTAN T | |
| Titolo: | Absolute Configurations of Globosuxanthone A and Secondary Metabolites from Microdiplodia sp. – A Novel Solid-State CD/TDDFT Approach | |
| Anno del prodotto: | 2007 | |
| Digital Object Identifier (DOI): | 10.1002/ejoc.200600789 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/111661
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