The use of cholic acid derivative 1, bearing a D-prolinamide moiety linked at the 12-position of cholic acid methylester, as an organocatalyst in the asymmetric aldol reaction of cyclic ketones and aromatic aldehydes, gave the corresponding aldol products in good yield and ee up to 98%. This organocatalyst has proven to be efficient both in water and in organic solvent, where it has been used with a 1% loading.
Methyl 12-D-prolinoylaminocholate as a versatile organocatalyst for the asymmetric aldol reaction of cyclic ketones
IULIANO, ANNA
2007-01-01
Abstract
The use of cholic acid derivative 1, bearing a D-prolinamide moiety linked at the 12-position of cholic acid methylester, as an organocatalyst in the asymmetric aldol reaction of cyclic ketones and aromatic aldehydes, gave the corresponding aldol products in good yield and ee up to 98%. This organocatalyst has proven to be efficient both in water and in organic solvent, where it has been used with a 1% loading.File in questo prodotto:
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