Here, we report the crystallization, structure determination and dissolution behaviour of the δ-polymorph of the non-steroidal anti-inflammatory drug indomethacin (IMC), a poorly studied polymorph first mentioned almost 50 years ago [4] and whose structure has remained hitherto unknown. δ-IMC shows a significantly enhanced dissolution rate compared with the more common and thoroughly studied α- and γ-polymorphs, potentially connected with an increased bioavailability.
Structure and stability of δ-indomethacin
Mugnaioli, Enrico;Gemmi, Mauro;Piras, Anna M.;Zambito, Ylenia
2021-01-01
Abstract
Here, we report the crystallization, structure determination and dissolution behaviour of the δ-polymorph of the non-steroidal anti-inflammatory drug indomethacin (IMC), a poorly studied polymorph first mentioned almost 50 years ago [4] and whose structure has remained hitherto unknown. δ-IMC shows a significantly enhanced dissolution rate compared with the more common and thoroughly studied α- and γ-polymorphs, potentially connected with an increased bioavailability.File in questo prodotto:
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