The present study evaluated the in vitro potency of ceftazidime and cefepime among carbapenem-resistant Pseudomonas aeruginosa isolates collected as part of a global surveillance program and assessed the pharmacodynamic implications using previously published population pharmacokinetics. When susceptible, MICs resulted at the high end of distribution for both ceftazidime and cefepime, thus 6 g/day was required to achieve optimal pharmacodynamic profiles. These findings should be considered in the clinic and for the application of CLSI susceptibility breakpoints.
Autori interni: | ||
Autori: | Gill, C. M.; Aktas, E.; Alfouzan, W.; Bourassa, L.; Brink, A.; Burnham, C. -A. D.; Canton, R.; Carmeli, Y.; Falcone, M.; Kiffer, C.; Marchese, A.; Martinez, O.; Pournaras, S.; Seifert, H.; Thabit, A. K.; Villegas, M. V.; Westblade, L. F.; Nicolau, D. P.; Wille, J.; Rezende, T. T. F.; Cekin, Z.; Malkocoglu, G.; Gijon, D.; Tarakmeh, L. A.; Chu, C. Y.; Opperman, C. J.; Tootla, H. D.; Moodley, C.; Coetzee, J.; Vourli, S.; Dimopoulos, G.; Attallah, D. M.; Tiseo, G.; Leonildi, A.; Giordano, C.; Barnini, S.; Menichetti, F.; Di Pilato, V.; Codda, G.; Vena, A.; Giacobbe, D. R.; Satlin, M.; Cardona, A.; Curtis, L.; Fang, F.; Thomson, G.; Thomson, K. | |
Titolo: | Elevated MICs of susceptible antipseudomonal cephalosporins in non-carbapenemase-producing, carbapenem-resistant pseudomonas aeruginosa: Implications for dose optimization | |
Anno del prodotto: | 2021 | |
Abstract: | The present study evaluated the in vitro potency of ceftazidime and cefepime among carbapenem-resistant Pseudomonas aeruginosa isolates collected as part of a global surveillance program and assessed the pharmacodynamic implications using previously published population pharmacokinetics. When susceptible, MICs resulted at the high end of distribution for both ceftazidime and cefepime, thus 6 g/day was required to achieve optimal pharmacodynamic profiles. These findings should be considered in the clinic and for the application of CLSI susceptibility breakpoints. | |
Digital Object Identifier (DOI): | 10.1128/AAC.01204-21 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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