The present study evaluated the in vitro potency of ceftazidime and cefepime among carbapenem-resistant Pseudomonas aeruginosa isolates collected as part of a global surveillance program and assessed the pharmacodynamic implications using previously published population pharmacokinetics. When susceptible, MICs resulted at the high end of distribution for both ceftazidime and cefepime, thus 6 g/day was required to achieve optimal pharmacodynamic profiles. These findings should be considered in the clinic and for the application of CLSI susceptibility breakpoints.

Elevated MICs of susceptible antipseudomonal cephalosporins in non-carbapenemase-producing, carbapenem-resistant pseudomonas aeruginosa: Implications for dose optimization

Falcone M.;Tiseo G.;Barnini S.;Menichetti F.;
2021

Abstract

The present study evaluated the in vitro potency of ceftazidime and cefepime among carbapenem-resistant Pseudomonas aeruginosa isolates collected as part of a global surveillance program and assessed the pharmacodynamic implications using previously published population pharmacokinetics. When susceptible, MICs resulted at the high end of distribution for both ceftazidime and cefepime, thus 6 g/day was required to achieve optimal pharmacodynamic profiles. These findings should be considered in the clinic and for the application of CLSI susceptibility breakpoints.
Gill, C. M.; Aktas, E.; Alfouzan, W.; Bourassa, L.; Brink, A.; Burnham, C. -A. D.; Canton, R.; Carmeli, Y.; Falcone, M.; Kiffer, C.; Marchese, A.; Martinez, O.; Pournaras, S.; Seifert, H.; Thabit, A. K.; Villegas, M. V.; Westblade, L. F.; Nicolau, D. P.; Wille, J.; Rezende, T. T. F.; Cekin, Z.; Malkocoglu, G.; Gijon, D.; Tarakmeh, L. A.; Chu, C. Y.; Opperman, C. J.; Tootla, H. D.; Moodley, C.; Coetzee, J.; Vourli, S.; Dimopoulos, G.; Attallah, D. M.; Tiseo, G.; Leonildi, A.; Giordano, C.; Barnini, S.; Menichetti, F.; Di Pilato, V.; Codda, G.; Vena, A.; Giacobbe, D. R.; Satlin, M.; Cardona, A.; Curtis, L.; Fang, F.; Thomson, G.; Thomson, K.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/1142141
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