Patients affected by lower urinary tract dysfunctions (LUTDs), such as overactive bladder, lose control of micturition with invalidating consequences on their physical, social and emotional well-being. Pudendal neuromodulation has been successfully used to treat LUTDs symptoms by injecting current through a tined lead electrode [1]. However, the epineural electrode migration compromised its efficacy and reliability [2]. Furthermore, to our knowledge, neuromodulation techniques can yet not restore the sensory perception of bladder fullness. Intraneural electrodes instead are inserted through the nerve enhancing electrode stability and providing a highly selective stimulation of nerves [3]. Intraneural stimulation has been proven to restore touch sensations in upper-limb amputees. Therefore, the selective stimulation of pudendal afferents could restore bladder fullness perception while the stimulation of efferents could restore the micturition process control. To investigate a novel approach to pudendal neuromodulation based on the use of intraneural electrodes, here we present a first explorative study on pig pudendal nerve surgical access and stimulation.

Surgical access and stimulation of pudendal nerve in pigs to restore the micturition control

Carla Lenzi;Elisabetta Giannessi;
2021

Abstract

Patients affected by lower urinary tract dysfunctions (LUTDs), such as overactive bladder, lose control of micturition with invalidating consequences on their physical, social and emotional well-being. Pudendal neuromodulation has been successfully used to treat LUTDs symptoms by injecting current through a tined lead electrode [1]. However, the epineural electrode migration compromised its efficacy and reliability [2]. Furthermore, to our knowledge, neuromodulation techniques can yet not restore the sensory perception of bladder fullness. Intraneural electrodes instead are inserted through the nerve enhancing electrode stability and providing a highly selective stimulation of nerves [3]. Intraneural stimulation has been proven to restore touch sensations in upper-limb amputees. Therefore, the selective stimulation of pudendal afferents could restore bladder fullness perception while the stimulation of efferents could restore the micturition process control. To investigate a novel approach to pudendal neuromodulation based on the use of intraneural electrodes, here we present a first explorative study on pig pudendal nerve surgical access and stimulation.
https://onlinelibrary.wiley.com/doi/10.1002/nau.24751
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/1146580
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