Experimental evidence suggests a key role of SIRT1 (silent information regulator 1) in age- and metabolic-related vascular dysfunction. Whether these effects hold true in the human microvasculature is unknown. We aimed to investigate the SIRT1 role in very early stages of age- and obesity-related microvascular dysfunction in humans.
Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels
Mengozzi, Alessandro
Primo
;Duranti, Emiliano;Nannipieri, Monica;Lai, Michele;La Rocca, Veronica;Puxeddu, Ilaria;Antonioli, Luca;Fornai, Matteo;Ghionzoli, Marco;Ippolito, Chiara;Bernardini, Nunzia;Pugliese, Nicola Riccardo;Taddei, Stefano;Virdis, AgostinoPenultimo
;Masi, StefanoUltimo
2022-01-01
Abstract
Experimental evidence suggests a key role of SIRT1 (silent information regulator 1) in age- and metabolic-related vascular dysfunction. Whether these effects hold true in the human microvasculature is unknown. We aimed to investigate the SIRT1 role in very early stages of age- and obesity-related microvascular dysfunction in humans.File in questo prodotto:
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