The chapter reviews the potential of epitaxial graphene grown on SiC in neuroregenerative medicine, with a special focus on graphene application as an active nerve guide in nerve tissue engineering, to enhance axon regeneration. We investigate the use of graphene on SiC as an ideal clean and high quality peripheral neural interface, starting with the nano-resolved analysis of graphene surface functionalized with the standard polymeric coating for neural cell culture and then moving to its interaction with two established models for peripheral neurons: PC12 cells and dorsal root ganglion primary neurons. The material shows good cytocompatibility and influence on differentiation and more interestingly it enhances axonal growth. Finally, recent developments in understanding the mechanistic details by which graphene would promote axon outgrowth are presented.
Graphene on SiC: platform for spinal cord repair studies
Marchetti, Laura
;
2022-01-01
Abstract
The chapter reviews the potential of epitaxial graphene grown on SiC in neuroregenerative medicine, with a special focus on graphene application as an active nerve guide in nerve tissue engineering, to enhance axon regeneration. We investigate the use of graphene on SiC as an ideal clean and high quality peripheral neural interface, starting with the nano-resolved analysis of graphene surface functionalized with the standard polymeric coating for neural cell culture and then moving to its interaction with two established models for peripheral neurons: PC12 cells and dorsal root ganglion primary neurons. The material shows good cytocompatibility and influence on differentiation and more interestingly it enhances axonal growth. Finally, recent developments in understanding the mechanistic details by which graphene would promote axon outgrowth are presented.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
