Atracheobronchial neuroendocrine carcinoma in a 10-year-old cat with a history of coughing, dyspnoea and anorexia is described. Endoscopic examination revealed a yellowish mass protruding into the trachea and partly obstructing the right bronchial lumen. Histological examination of biopsy samples revealed a hypercellular tumour consisting of sheets or ribbons of small hyperchromatic cells, with oval to spindle-shaped nuclei and minimal cytoplasm; nucleoli and mitotic activity were absent. The ¢ndings were con¢rmed on post-mortem examination. The small neoplastic cells were immunolabelled to varying degrees by antibodies against neuronspeci¢ c enolase, S-100 protein, synaptophysin and vimentin. Ultrastructural studies revealed scattered neurosecretory granules and scanty cellular junctional complexes, including desmosomes andtono¢laments, in neoplastic cells.
|Autori:||ROSSI GIACOMO; MAGI GIANENRICO; TARANTINO CHIARA; MARI SUBEIDE; PENGO GRAZIANO; TACCINI E; RENZONI GIACOMO|
|Titolo:||Tracheobronchial neuroendocrine carcinoma in a cat|
|Anno del prodotto:||2007|
|Appare nelle tipologie:||1.1 Articolo in rivista|