Aim: To assess the prognostic relevance of baseline and post-treatment skeletal muscle index (SMI) and skeletal muscle radiation attenuation (SMRA) at the level of third lumbar vertebra in patients with ovarian cancer who underwent primary surgery and platinum-based chemotherapy. Patients and Methods: This retrospective investigation analyzed 134 patients who underwent staging computed tomography, surgery, chemotherapy and posttreatment computed tomography. Results: At univariate analysis, stage (p<0.0001), histotype (p=0.01), residual disease (p<0.0001) and treatment response (p<0.0001) correlated with progression-free survival (PFS), whereas age (p=0.004), stage (p=0.006), residual disease (p<0.0001) and treatment response (p<0.0001) were associated with overall survival (OS). Neither baseline nor post-treatment SMI and SMRA had prognostic relevance. At multivariate analysis, residual disease and treatment response correlated with PFS (p<0.0001 and p<0.0001) and OS (p=0.007 and p<0.0001), whilst age was an independent prognostic variable for OS (p=0.02). Conclusion: Baseline and post-treatment SMI and SMRA did not correlate with patient outcome in this clinical setting.

Computed Tomography-assessed Skeletal Muscle Index and Skeletal Muscle Radiation Attenuation in Patients With Ovarian Cancer Treated With Primary Surgery Followed by Platinum-based Chemotherapy: A Single-center Italian Study

Gadducci, Angiolo
;
Simonetti, Enrico;Miccoli, Mario;Frey, Jessica;Neri, Emanuele
2022-01-01

Abstract

Aim: To assess the prognostic relevance of baseline and post-treatment skeletal muscle index (SMI) and skeletal muscle radiation attenuation (SMRA) at the level of third lumbar vertebra in patients with ovarian cancer who underwent primary surgery and platinum-based chemotherapy. Patients and Methods: This retrospective investigation analyzed 134 patients who underwent staging computed tomography, surgery, chemotherapy and posttreatment computed tomography. Results: At univariate analysis, stage (p<0.0001), histotype (p=0.01), residual disease (p<0.0001) and treatment response (p<0.0001) correlated with progression-free survival (PFS), whereas age (p=0.004), stage (p=0.006), residual disease (p<0.0001) and treatment response (p<0.0001) were associated with overall survival (OS). Neither baseline nor post-treatment SMI and SMRA had prognostic relevance. At multivariate analysis, residual disease and treatment response correlated with PFS (p<0.0001 and p<0.0001) and OS (p=0.007 and p<0.0001), whilst age was an independent prognostic variable for OS (p=0.02). Conclusion: Baseline and post-treatment SMI and SMRA did not correlate with patient outcome in this clinical setting.
2022
Gadducci, Angiolo; Simonetti, Enrico; Mezzapesa, Francesco; Cosio, Stefania; Miccoli, Mario; Frey, Jessica; Tintori, Rachele; Bulleri, Alessandra; Ner...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1160151
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