The liver represents the most frequent location of metastatic disease in colorectal cancer (CRC). In oligometastatic disease, while surgery remains the mainstay of treatment, loco-regional therapies allow to locally control tumor progression and prolong survival. There is consensus in the use of transhepatic arterial radioembolization (TARE) in metastatic CRC chemorefractory patients, with liver-only or liver-dominant disease. Beyond this indication, TARE may be considered in other clinical scenarios, such as in the second-line combined with chemotherapy, as a bridge in between different lines of systemic therapies, and as ablative technique under specific circumstances. This paper outlines the current evidence for TARE in mCRC and presents possible future indications and directions

Role of Transhepatic Arterial Radioembolization in Metastatic Colorectal Cancer

Boni, Giuseppe;Masi, Gianluca;Cioni, Roberto;Crocetti, Laura
2022-01-01

Abstract

The liver represents the most frequent location of metastatic disease in colorectal cancer (CRC). In oligometastatic disease, while surgery remains the mainstay of treatment, loco-regional therapies allow to locally control tumor progression and prolong survival. There is consensus in the use of transhepatic arterial radioembolization (TARE) in metastatic CRC chemorefractory patients, with liver-only or liver-dominant disease. Beyond this indication, TARE may be considered in other clinical scenarios, such as in the second-line combined with chemotherapy, as a bridge in between different lines of systemic therapies, and as ablative technique under specific circumstances. This paper outlines the current evidence for TARE in mCRC and presents possible future indications and directions
2022
Bargellini, Irene; Bozzi, Elena; Lorenzoni, Giulia; Boni, Giuseppe; Bianchi, Francesca; Traino, Claudio Antonio; Masi, Gianluca; Cioni, Roberto; Crocetti, Laura
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1160221
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