BACKGROUND AND PURPOSE Microparticles (MPs), small membrane-bound particles originating from different cell types during activation or apoptosis, mediate intercellular communication, exert pro-coagulant activity and affect inflammation and other pathophysiological conditions. Monocyte-derived MPs have undergone little investigation and, to our knowledge, have never been evaluated for their possible autocrine effects. Therefore, we assessed the ability of monocyte-derived MPs to stimulate human monocytes and monocyte-derived macrophages (MDM).
Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands
Neri T.;Celi A.;
2012-01-01
Abstract
BACKGROUND AND PURPOSE Microparticles (MPs), small membrane-bound particles originating from different cell types during activation or apoptosis, mediate intercellular communication, exert pro-coagulant activity and affect inflammation and other pathophysiological conditions. Monocyte-derived MPs have undergone little investigation and, to our knowledge, have never been evaluated for their possible autocrine effects. Therefore, we assessed the ability of monocyte-derived MPs to stimulate human monocytes and monocyte-derived macrophages (MDM).File in questo prodotto:
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British J Pharmacology - 2011 - Bardelli - Autocrine activation of human monocyte macrophages by monocyte‐derived.pdf
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