Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our data demonstrate that anti-GSTO1-1 antibodies can be found also in different types of inflammatory diseases, such as autoimmune rheumatoid arthritis and infectious SARS-CoV-2 and trichinellosis. Our data strongly suggest that anti-GSTO1-1 antibodies could represent a marker of tissue damage/inflammation rather than a type of specific tumor-associated biomarker only.

Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans

Piaggi, Simona;Lorenzini, Evelina;Pratesi, Federico;Migliorini, Paola;Pompella, Alfonso;Bruschi, Fabrizio;Corti, Alessandro
2022-01-01

Abstract

Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our data demonstrate that anti-GSTO1-1 antibodies can be found also in different types of inflammatory diseases, such as autoimmune rheumatoid arthritis and infectious SARS-CoV-2 and trichinellosis. Our data strongly suggest that anti-GSTO1-1 antibodies could represent a marker of tissue damage/inflammation rather than a type of specific tumor-associated biomarker only.
2022
Piaggi, Simona; Lorenzini, Evelina; Pratesi, Federico; Migliorini, Paola; Pompella, Alfonso; Bruschi, Fabrizio; Corti, Alessandro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1160912
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