Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our data demonstrate that anti-GSTO1-1 antibodies can be found also in different types of inflammatory diseases, such as autoimmune rheumatoid arthritis and infectious SARS-CoV-2 and trichinellosis. Our data strongly suggest that anti-GSTO1-1 antibodies could represent a marker of tissue damage/inflammation rather than a type of specific tumor-associated biomarker only.
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans
Piaggi, Simona;Lorenzini, Evelina;Pratesi, Federico;Migliorini, Paola;Pompella, Alfonso;Bruschi, Fabrizio;Corti, Alessandro
2022-01-01
Abstract
Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our data demonstrate that anti-GSTO1-1 antibodies can be found also in different types of inflammatory diseases, such as autoimmune rheumatoid arthritis and infectious SARS-CoV-2 and trichinellosis. Our data strongly suggest that anti-GSTO1-1 antibodies could represent a marker of tissue damage/inflammation rather than a type of specific tumor-associated biomarker only.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
