Introduction: Eosinophilic esophagitis (EoE) requires maintenance therapy to avoid recurrence. We investigated the efficacy of a second course of proton pump inhibitors (scPPIs) to maintain steroid-induced histological remission (HR) in patients with EoE who had previously failed induction of remission with PPIs. Methods: We retrospectively included 18 patients who achieved HR with topical steroids but could not be maintained on long-term topical steroids. Treatment outcomes were assessed after 12 weeks of scPPIs. Results: Most of the patients (67%) maintained HR with high-dose PPI monotherapy at week 12. Discussion: scPPIs might work as a maintenance strategy in primary PPI nonresponder EoE patients.
Efficacy of a Second PPI Course After Steroid-Induced Remission in Eosinophilic Esophagitis Refractory to Initial PPI Therapy
Visaggi, PierfrancescoPrimo
Writing – Original Draft Preparation
;Baiano Svizzero, FedericaSecondo
Writing – Original Draft Preparation
;Del Corso, GiulioFormal Analysis
;Bellini, MassimoMembro del Collaboration Group
;de Bortoli, Nicola
Ultimo
Writing – Original Draft Preparation
2022-01-01
Abstract
Introduction: Eosinophilic esophagitis (EoE) requires maintenance therapy to avoid recurrence. We investigated the efficacy of a second course of proton pump inhibitors (scPPIs) to maintain steroid-induced histological remission (HR) in patients with EoE who had previously failed induction of remission with PPIs. Methods: We retrospectively included 18 patients who achieved HR with topical steroids but could not be maintained on long-term topical steroids. Treatment outcomes were assessed after 12 weeks of scPPIs. Results: Most of the patients (67%) maintained HR with high-dose PPI monotherapy at week 12. Discussion: scPPIs might work as a maintenance strategy in primary PPI nonresponder EoE patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
