Urticarial vasculitis (UV) is a small-vessel leukocytoclastic vasculitis characterized by different clinical manifestations ranging from long-lasting urticarial lesions to severe and potentially life-threatening multi-organ involvement. Omalizumab (OMA), anti-IgE recombinant humanized IgG1 monoclonal antibody, has been successfully used to treat few cases of severe and/or refractory UV. In this study we report our experience on 6 patients with refractory normocomplementemic UV successfully treated with anti-IgE therapy (OMA), suggesting that this biological therapy may be a safe and effective therapeutic option in UV.

Efficacy and safety of omalizumab therapy in urticaria vasculitis

Petrelli, Fiorella;Giannini, Daiana;Bilia, Silvia;Rocchi, Valeria;Migliorini, Paola;Puxeddu, Ilaria
2022-01-01

Abstract

Urticarial vasculitis (UV) is a small-vessel leukocytoclastic vasculitis characterized by different clinical manifestations ranging from long-lasting urticarial lesions to severe and potentially life-threatening multi-organ involvement. Omalizumab (OMA), anti-IgE recombinant humanized IgG1 monoclonal antibody, has been successfully used to treat few cases of severe and/or refractory UV. In this study we report our experience on 6 patients with refractory normocomplementemic UV successfully treated with anti-IgE therapy (OMA), suggesting that this biological therapy may be a safe and effective therapeutic option in UV.
2022
Petrelli, Fiorella; Giannini, Daiana; Bilia, Silvia; Corso, Isabella Del; Rocchi, Valeria; Migliorini, Paola; Puxeddu, Ilaria
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1160994
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