Metal compounds form an attractive class of ligands for a variety of nucleic acids. Five metal complexes bearing aminopyridyl-2,2 '-bipyridine tetradentate ligands and possessing a quasi-planar geometry were challenged toward different types of nucleic acid molecules including RNA polynucleotides in the duplex or triplex form, an RNA Holliday four-way junction, natural double helix DNA and a DNA G-quadruplex. The binding process was monitored comparatively using different spectroscopic and melting methods. The binding preferences that emerge from our analysis are discussed in relation to the structural features of the metal complexes.

A biophysical study of the interactions of palladium(II), platinum(II) and gold(III) complexes of aminopyridyl-2,2'-bipyridine ligands with RNAs and other nucleic acid structures

Binacchi, Francesca
Primo
;
Cirri, Damiano;Pratesi, Alessandro
Penultimo
;
Biver, Tarita
Ultimo
2022-01-01

Abstract

Metal compounds form an attractive class of ligands for a variety of nucleic acids. Five metal complexes bearing aminopyridyl-2,2 '-bipyridine tetradentate ligands and possessing a quasi-planar geometry were challenged toward different types of nucleic acid molecules including RNA polynucleotides in the duplex or triplex form, an RNA Holliday four-way junction, natural double helix DNA and a DNA G-quadruplex. The binding process was monitored comparatively using different spectroscopic and melting methods. The binding preferences that emerge from our analysis are discussed in relation to the structural features of the metal complexes.
2022
Binacchi, Francesca; Elia, Cassandra; Cirri, Damiano; Van de Griend, Corjan; Zhou, Xue-Quan; Messori, Luigi; Bonnet, Sylvestre; Pratesi, Alessandro; Biver, Tarita
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1163205
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