Introduction: Hepatitis C virus (HCV) can cause lymphoproliferative disorders (LPDs). The most frequent one is mixed cryoglobulinemia (MC), clinically benign, but evolving in about 10% of cases into a non-Hodgkin's lymphoma (NHL). Recently, a GWAS allowed the discovery of an association of two SNPs on chromosome 6 and HCV-related MC; the first one is an intronic SNP (rs2071286) of the NOTCH4 gene, the second one (rs9461776) is located between HLA-DRB1 and HLA-DQA1 gene segments.Aim: To define the contribution of rs2071286 and rs9461776 in the predisposition to develop HCV-related LPDs.

NOTCH4 AND MHC CLASS II POLYMORPHISMS CONTRIBUTE TO HCV-RELATED BENIGN AND MALIGNANT LYMPHOPROLIFERATIVE DISEASES

Gragnani L;
2015-01-01

Abstract

Introduction: Hepatitis C virus (HCV) can cause lymphoproliferative disorders (LPDs). The most frequent one is mixed cryoglobulinemia (MC), clinically benign, but evolving in about 10% of cases into a non-Hodgkin's lymphoma (NHL). Recently, a GWAS allowed the discovery of an association of two SNPs on chromosome 6 and HCV-related MC; the first one is an intronic SNP (rs2071286) of the NOTCH4 gene, the second one (rs9461776) is located between HLA-DRB1 and HLA-DQA1 gene segments.Aim: To define the contribution of rs2071286 and rs9461776 in the predisposition to develop HCV-related LPDs.
https://www.dldjournalonline.com/article/S1590-8658(15)00055-9/fulltext
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1163424
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