Ultrasound Cyclo Plasty in Patients with Open Angle Glaucoma and High Myopia

Prcis: Ultrasound cycloplasty (UCP) using high-intensity focused ultrasound (HIFU) is an effective and safe procedure in lowering intraocular pressure (IOP) in patients with glaucoma, even in those with high myopia. Purpose: This study aimed to evaluate the efficacy and safety of UCP in glaucoma patients with high-myopia. Methods: In this retrospective, single-center study, we enrolled 36 eyes divided into two groups based on axial length: group A (≥26.00 mm) and group B (<26.00 mm). We collected data about visual acuity, Goldmann applanation tonometry, biomicroscopy, and visual field before the procedure and at 1, 7, 30, 60, 90, 180, and 365 days after the procedure. Results: Mean IOP significantly decreased in both groups after treatment (P<0.001). Mean IOP reduction from baseline to the last visit was 9.8±6.6 mmHg (38.7%) in group A and 9.6±6.3 mmHg (34.8%) in group B (P<0.001). Mean IOP at the last visit was 15.8±4.1 mmHg in the myopic group and 18.1±5.6 mmHg in the non-myopic one. Regarding the number of IOP-lowering eyedrops being taken by our patients, no statistically significant differences were found between groups A and B at baseline (2.8±0.9 and 2.6±1.0; P=0.568) nor 1 year after the procedure (2.5±1.1 and 2.6±1.1; P=0.762). No major complications occurred. All minor adverse events resolved within a few days. Conclusion: UCP seems to be an effective and well-tolerated strategy to lower IOP in glaucoma patients with high-myopia.