The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug–protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme
GABBIANI, CHIARA;
2007-01-01
Abstract
The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug–protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 Å resolution, reveals selective platination of imidazole Nε of His15.File in questo prodotto:
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