The present invention relates to the use of an endogenous protein of immunitary origin, fractalkine, as a neuroprotective agent against glutamate toxicity in case of acute cerebral ischemia and spinal cord lesions. The agent is useful also in neurosurgery during operations on the brain as neuroprotective agent in case of blockage of blood circulation in the localized brain region subject to surgical intervention. Neuroprotection is exerted in the interval of a few hours after the ischemic insult and thus should be considered unique in the described pathophysiological applications.
Use of fractalkine for the production of a neuroprotector drug against cell death
FORNAI, FRANCESCO;
2007-01-01
Abstract
The present invention relates to the use of an endogenous protein of immunitary origin, fractalkine, as a neuroprotective agent against glutamate toxicity in case of acute cerebral ischemia and spinal cord lesions. The agent is useful also in neurosurgery during operations on the brain as neuroprotective agent in case of blockage of blood circulation in the localized brain region subject to surgical intervention. Neuroprotection is exerted in the interval of a few hours after the ischemic insult and thus should be considered unique in the described pathophysiological applications.File in questo prodotto:
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