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EnglishBrain beta-endorphin (beta-EP) plays an important role in regulating the hypothalamus-pituitary-gonadal axis activity. Cerebrospinal fluid (CSF) beta-EP levels seem to reflect the central rather than pituitary secretion. With the aim to correlate the changes of plasma estradiol (E2), progesterone, luteinizing hormone (LH) and follicle-stimulating hormone with brain beta-EP, CSF levels of beta-EP were measured in 15 normally cycling and 15 postmenopausal women. CSF beta-EP levels in post-menopausal women were lower than in fertile women. A positive correlation between plasma E2 and CSF beta-EP level was found in all women. In fertile women CSF beta-EP levels were inversely correlated to plasma gonadotropin levels. These results showed that CSF beta-EP levels differ between fertile and postmenopausal women and are correlated with plasma LH and E2, suggesting a strong linkage between central beta-EP levels and pituitary-gonadal axis hormones.
| Autori interni: | ||
| Autori: | Nappi C; Petraglia F; Gambardella A; De Masellis G; Di Carlo C; Genazzani A; Montemagno U | |
| Titolo: | Relationship between cerebrospinal fluid beta-endorphin and plasma pituitary-gonadal hormone levels in women. | |
| Anno del prodotto: | 1990 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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