Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucially, our understanding of its clinical presentation, course, and optimal treatment remains limited, and few advancements in improving its management have been made in the recent past. Methods We conducted an international multicenter retrospective analysis of 505 SNMM cases from 11 institutions across the United States, United Kingdom, Ireland, and continental Europe. Data on clinical presentation, diagnosis, treatment, and clinical outcomes were assessed. Results One-, three-, and five-year recurrence-free and overall survival were 61.4, 30.6, and 22.0%, and 77.6, 49.2, and 38.3%, respectively. Compared with disease confined to the nasal cavity, sinus involvement confers significantly worse survival; based on this, further stratifying the T3 stage was highly prognostic ( p < 0.001) with implications for a potential modification to the current TNM staging system. There was a statistically significant survival benefit for patients who received adjuvant radiotherapy, compared with those who underwent surgery alone (hazard ratio [HR] = 0.74, 95% confidence interval [CI]: 0.57-0.96, p = 0.021). Immune checkpoint blockade for the management of recurrent or persistent disease, with or without distant metastasis, conferred longer survival (HR = 0.50, 95% CI: 0.25-1.00, p = 0.036). Conclusions We present findings from the largest cohort of SNMM reported to date. We demonstrate the potential utility of further stratifying the T3 stage by sinus involvement and present promising data on the benefit of immune checkpoint inhibitors for recurrent, persistent, or metastatic disease with implications for future clinical trials in this field.

International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System

Franchi, Alessandro;
2023-01-01

Abstract

Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucially, our understanding of its clinical presentation, course, and optimal treatment remains limited, and few advancements in improving its management have been made in the recent past. Methods We conducted an international multicenter retrospective analysis of 505 SNMM cases from 11 institutions across the United States, United Kingdom, Ireland, and continental Europe. Data on clinical presentation, diagnosis, treatment, and clinical outcomes were assessed. Results One-, three-, and five-year recurrence-free and overall survival were 61.4, 30.6, and 22.0%, and 77.6, 49.2, and 38.3%, respectively. Compared with disease confined to the nasal cavity, sinus involvement confers significantly worse survival; based on this, further stratifying the T3 stage was highly prognostic ( p < 0.001) with implications for a potential modification to the current TNM staging system. There was a statistically significant survival benefit for patients who received adjuvant radiotherapy, compared with those who underwent surgery alone (hazard ratio [HR] = 0.74, 95% confidence interval [CI]: 0.57-0.96, p = 0.021). Immune checkpoint blockade for the management of recurrent or persistent disease, with or without distant metastasis, conferred longer survival (HR = 0.50, 95% CI: 0.25-1.00, p = 0.036). Conclusions We present findings from the largest cohort of SNMM reported to date. We demonstrate the potential utility of further stratifying the T3 stage by sinus involvement and present promising data on the benefit of immune checkpoint inhibitors for recurrent, persistent, or metastatic disease with implications for future clinical trials in this field.
2023
Lechner, Matt; Takahashi, Yoko; Turri-Zanoni, Mario; Ferrari, Marco; Liu, Jacklyn; Counsell, Nicholas; Mattavelli, Davide; Rampinelli, Vittorio; Vermi, William; Lombardi, Davide; Saade, Rami; Park, Ki Wan; Schartinger, Volker H; Franchi, Alessandro; Facco, Carla; Sessa, Fausto; Battocchio, Simonetta; Fenton, Tim R; Vaz, Francis M; O'Flynn, Paul; Howard, David; Stimpson, Paul; Wang, Simon; Hannan, S Alam; Unadkat, Samit; Hughes, Jonathan; Dwivedi, Raghav; Forde, Cillian T; Randhawa, Premjit; Gane, Simon; Joseph, Jonathan; Andrews, Peter J; Dave, Manas; Fleming, Jason C; Thomson, David; Zhu, Tianyu; Teschendorff, Andrew; Royle, Gary; Steele, Christopher; Jimenez, Joaquin E; Laco, Jan; Wang, Eric W; Snyderman, Carl; Lacy, Peter D; Woods, Robbie; O'Neill, James P; Saraswathula, Anirudh; Kaur, Raman Preet; Zhao, Tianna; Ramanathan, Murugappan; Gallia, Gary L; London, Nyall R; Le, Quynh-Thu; West, Robert B; Patel, Zara M; Nayak, Jayakar V; Hwang, Peter H; Hermsen, Mario; Llorente, Jose; Facchetti, Fabio; Nicolai, Piero; Bossi, Paolo; Castelnuovo, Paolo; Jay, Amrita; Carnell, Dawn; Forster, Martin D; Bell, Diana M; Lund, Valerie J; Hanna, Ehab Y
File in questo prodotto:
File Dimensione Formato  
International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma.pdf

non disponibili

Tipologia: Versione finale editoriale
Licenza: NON PUBBLICO - accesso privato/ristretto
Dimensione 851.9 kB
Formato Adobe PDF
851.9 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1195587
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 15
social impact