In the context of Precision Medicine for Alzheimer's Disease, the assessment of the central noradrenergic system might be key for optimizing the management of cognitively impaired patients. The Locus Coeruleus, the main noradrenergic nucleus of the brain, is involved early and dramatically in Alzheimer's Disease, and the loss of its function may have detrimental consequences. Recent advances in diagnostic technology have enabled in vivo evaluation of the integrity and functionality of the Locus Coeruleus, revealing the characteristics of this otherwise hidden nucleus. This new perspective may lead to novel therapeutic approaches that specifically target the noradrenergic system in Alzheimer's Disease.
The role of brain noradrenaline in Alzheimer's disease: Implications for a precision medicine-oriented approach
Galgani, A.Primo
;Giorgi, F. S.
Ultimo
2023-01-01
Abstract
In the context of Precision Medicine for Alzheimer's Disease, the assessment of the central noradrenergic system might be key for optimizing the management of cognitively impaired patients. The Locus Coeruleus, the main noradrenergic nucleus of the brain, is involved early and dramatically in Alzheimer's Disease, and the loss of its function may have detrimental consequences. Recent advances in diagnostic technology have enabled in vivo evaluation of the integrity and functionality of the Locus Coeruleus, revealing the characteristics of this otherwise hidden nucleus. This new perspective may lead to novel therapeutic approaches that specifically target the noradrenergic system in Alzheimer's Disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
