Mice infected subcutaneously with 2 X 10(7) CFU of Mycobacterium bovis strain BCG (BCG) were able to mount a specific DTH response, whereas mice infected intravenously with the same dose of microorganisms were not. The suppression turned out to be mediated by id+ anti-PPD B lymphocytes, which arose very early during the infectious process and induced anti-id B lymphocytes. These cells were found at Day 4 after infection and exerted their effect by activating antigen-specific suppressor T lymphocytes, which affected the efferent phase of the DTH response. These results clearly indicate that the activation of a complex immunosuppressive circuit represents a mechanism by which BCG may interfere with the host's immune response already during the very early phases of infection.
|Autori:||CAMPA M; BENEDETTINI G; MARELLI P|
|Titolo:||LYMPHOCYTES-B AND LYMPHOCYTES-T REGULATED BY IDIOTYPE ANTIIDIOTYPE INTERACTIONS INHIBIT DELAYED-TYPE HYPERSENSITIVITY TO BCG IN MICE|
|Anno del prodotto:||1986|
|Digital Object Identifier (DOI):||10.1016/0008-8749(86)90270-4|
|Appare nelle tipologie:||1.1 Articolo in rivista|