A series of 1,3-diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones were prepared and tested for their ability to displace [3H]flunitrazepam from bovine brain membranes. While the 1,3-diarylpyrazolo[4,5-c]quinoline derivatives showed affinity for the receptor site, their [5,4-c] isomers were devoid of binding activity.

1,3-DIARYLPYRAZOLO[4,5-C]QUINOLIN-4-ONES AND 1,3-DIARYLPYRAZOLO[5,4-C]QUINOLIN-4-ONES .4. SYNTHESIS AND SPECIFIC-INHIBITION OF BENZODIAZEPINE RECEPTOR-BINDING

MARTINI, CLAUDIA;LUCACCHINI, ANTONIO
1987

Abstract

A series of 1,3-diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones were prepared and tested for their ability to displace [3H]flunitrazepam from bovine brain membranes. While the 1,3-diarylpyrazolo[4,5-c]quinoline derivatives showed affinity for the receptor site, their [5,4-c] isomers were devoid of binding activity.
Palazzino, G; Cecchi, L; Melani, F; Colotta, V; Filacchioni, G; Martini, Claudia; Lucacchini, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/12062
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