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EnglishDerivatives of 7-amino-2-dialkylaminoalkyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione with effect against cataract By: Bianchini, Pietro; Da Settimo, Federico Assignee: Farmigea S.p.A., Italy The title compds. (I; R,R2 = H, Me, Et; R1 = H, Cl; R3, R4 = Me, Et, Me2CH; NR3R4 = pyrrolidinyl, piperidinyl, N-methylpiperazinyl, morpholinyl, β-hydroxyethylpiperazinyl, etc.; n = 2,3) were prepd. Thus, 3-aminopyridine-4,5-dicarboxylic acid and H2NCH2CH2NEt2 were heated at 170° for 2 h to give II. II at 100 mg/kg orally in rats gave 35.17 inhibition of galactose-induced cataract formation.
| Titolo: | Derivatives of 7-amino-2-dialkylaminoalkyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione with effect against cataract | |
| Autori interni: | ||
| Anno di deposito: | 1990 | |
| Abstract: | Derivatives of 7-amino-2-dialkylaminoalkyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione with effect against cataract By: Bianchini, Pietro; Da Settimo, Federico Assignee: Farmigea S.p.A., Italy The title compds. (I; R,R2 = H, Me, Et; R1 = H, Cl; R3, R4 = Me, Et, Me2CH; NR3R4 = pyrrolidinyl, piperidinyl, N-methylpiperazinyl, morpholinyl, β-hydroxyethylpiperazinyl, etc.; n = 2,3) were prepd. Thus, 3-aminopyridine-4,5-dicarboxylic acid and H2NCH2CH2NEt2 were heated at 170° for 2 h to give II. II at 100 mg/kg orally in rats gave 35.17 inhibition of galactose-induced cataract formation. | |
| Handle: | http://hdl.handle.net/11568/12152 | |
| Appare nelle tipologie: | 6.1 Brevetto |
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