In hypothyroid patients needing large doses of levothyroxine (L-T4) (>1.7-2 μg/kg/day) to reach euthyroidism, lactose intolerance (LI) needs to be excluded, owing to the high prevalence in the population. If LI is present, a lactose-free diet decreases the rate of L-T4 malabsorption. However, an increased requirement of L-T4 is described in patients with LI, which can be beneficially treated using lactose-free L-T4 formulation. The lactose-free liquid L-T4 formulation is able to circumvent LI malabsorption leading to the normalization of thyroid-stimulating hormone (TSH) in patients with subclinical hypothyroidism and long-term stable TSH levels.

Lactose intolerance and levothyroxine malabsorption: a review of the literature and report of a series of patients treated with liquid L-T4 without lactose

Ferrari, Silvia Martina;Patrizio, Armando;Mazzi, Valeria;Ragusa, Francesca;Botrini, Chiara;Elia, Giusy;Balestri, Eugenia;Rugani, Licia;Bracchitta, Fabiana;Stoppini, Giulio;Frenzilli, Giada;Fallahi, Poupak;Antonelli, Alessandro
2024-01-01

Abstract

In hypothyroid patients needing large doses of levothyroxine (L-T4) (>1.7-2 μg/kg/day) to reach euthyroidism, lactose intolerance (LI) needs to be excluded, owing to the high prevalence in the population. If LI is present, a lactose-free diet decreases the rate of L-T4 malabsorption. However, an increased requirement of L-T4 is described in patients with LI, which can be beneficially treated using lactose-free L-T4 formulation. The lactose-free liquid L-T4 formulation is able to circumvent LI malabsorption leading to the normalization of thyroid-stimulating hormone (TSH) in patients with subclinical hypothyroidism and long-term stable TSH levels.
2024
Ferrari, Silvia Martina; Patrizio, Armando; Mazzi, Valeria; Ragusa, Francesca; Botrini, Chiara; Elia, Giusy; Balestri, Eugenia; Barozzi, Emilio; Rugani, Licia; Bracchitta, Fabiana; Stoppini, Giulio; Frenzilli, Giada; Baldini, Enke; Virili, Camilla; Benvenga, Salvatore; Fallahi, Poupak; Antonelli, Alessandro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/1240287
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