• There are not standard guidelines for the selection and treatment of patients with synchronous multiple nodules with ground glass/lepidic features. • The presence of different EGFR mutations in the various resected nodules with ground glass/lepidic features suggests the existence of multifocal primary tumors. • The results suggest the possibility that a germline mutation in an oncogene could facilitate the development of a tumor with additional mutations in the same oncogene
A patient with a Germline (p.R776H) EGFR Mutation With Multiple Lung Cancers Harboring Different Somatic EGFR Mutations
Petrini, Iacopo;Bruno, Rossella;Aprile, Vittorio;Korasidis, Stylianos;Alì, Greta
2024-01-01
Abstract
• There are not standard guidelines for the selection and treatment of patients with synchronous multiple nodules with ground glass/lepidic features. • The presence of different EGFR mutations in the various resected nodules with ground glass/lepidic features suggests the existence of multifocal primary tumors. • The results suggest the possibility that a germline mutation in an oncogene could facilitate the development of a tumor with additional mutations in the same oncogeneFile in questo prodotto:
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