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EnglishDiabetes mellitus has been defined as a "group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both" and encompasses a wide range of heterogeneous conditions. Common type 2 diabetes mellitus (T2DM) results from a combination of genetic and acquired factors. However, lifestyle factors, particularly overeating and physical inactivity, are the major clinical determinants of T2DM. Insulin resistance is a common feature of T2DM, but it is unlikely to cause T2DM unless progressive loss of beta-cell function develops. Significant reduction in beta-cell function is already present at the time of T2DM diagnosis, and it continuously declines irrespective of treatment. As such, the progressive loss of beta-cell function dictates the rate of worsened glycemic control. Development of progressive deterioration accelerates via gluco- and lipotoxicity, loss of beta-cell function, and shrinkage of beta-cell mass. Understanding the causes for beta-cell failure is therefore of capital importance to develop new and more effective therapeutic strategies.
| Autori interni: | |
| Autori: | Lencioni C; Lupi R; Del Prato S |
| Titolo: | beta-Cell Failure in Type 2 Diabetes Mellitus |
| Anno del prodotto: | 2008 |
| Digital Object Identifier (DOI): | 10.1007/s11892-008-0031-0 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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