Four new cyclopeptides, named gypsins A-D (1-4), together with one known oleanane saponin, were isolated from the roots of Gypsophila arabica. The structures of cyclo(-Leu1-Pro2-Leu3-Trp4-Pro5-Gly6-) (1), cyclo(-Leu1-Pro2-Tyr3-Phe4-Pro5-Gly6-) (2), cyclo(-Ala1-Pro2-Tyr3-Leu4-Leu5-Pro6-Pro7-Ala8-) (3), and cyclo(-Leu1-Trp2-Pro3-Gly4-Gly5-Ser6-Ser7-) (4) were elucidated by 1D and 2D NMR spectroscopy including 1D-TOCSY, DQF-COSY, 2D-ROESY, HSQC, and HMBC expts., as well as ESI tandem mass spectrometric fragmentation anal. and chem. evidence.
Gypsins A-D from Gypsophila arabica
BRACA, ALESSANDRA
2008-01-01
Abstract
Four new cyclopeptides, named gypsins A-D (1-4), together with one known oleanane saponin, were isolated from the roots of Gypsophila arabica. The structures of cyclo(-Leu1-Pro2-Leu3-Trp4-Pro5-Gly6-) (1), cyclo(-Leu1-Pro2-Tyr3-Phe4-Pro5-Gly6-) (2), cyclo(-Ala1-Pro2-Tyr3-Leu4-Leu5-Pro6-Pro7-Ala8-) (3), and cyclo(-Leu1-Trp2-Pro3-Gly4-Gly5-Ser6-Ser7-) (4) were elucidated by 1D and 2D NMR spectroscopy including 1D-TOCSY, DQF-COSY, 2D-ROESY, HSQC, and HMBC expts., as well as ESI tandem mass spectrometric fragmentation anal. and chem. evidence.File in questo prodotto:
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