The isolation and structure characterization of a dienone from the roots of Echinacea pallida, namely (8Z,11Z)-pentadeca-8,11-dien-2-one, are described here. To assess the configuration of this secondary metabolite, the stereoselective total synthesis of the two isomeric forms, (8Z,11Z)- and (8Z,11E)-pentadeca-8,11-dien-2-one, was undertaken and the structure elucidation of the natural compound was unambiguously carried out. The cytotoxic activity of both isomers was also evaluated on a human T cell leukaemia cancer line (Jurkat cells). The results indicated that these compounds exert a dose-dependent cytotoxicity with a medium-level potency on the tested cell line.
|Autori:||Morandi, S; Pellati, F; Ori, C; Adinolfi, B; Nieri, Paola; Benvenuti, S; Prati, F.|
|Titolo:||Isolation, structure elucidation and total synthesis of a cytotoxic dienone from Echinacea pallida|
|Anno del prodotto:||2008|
|Appare nelle tipologie:||1.1 Articolo in rivista|