Abstract We evaluated the impact of World Health Organization (WHO) classification and WHO classification-based Prognostic Scoring System (WPSS) on the outcome of patients with myelodysplastic syndrome (MDS) who underwent allogeneic stem cell transplantation (allo-SCT) between 1990 and 2006. Five-year overall survival (OS) was 80% in refractory anemias, 57% in refractory cytopenias, 51% in refractory anemia with excess blasts 1 (RAEB-1), 28% in RAEB-2, and 25% in acute leukemia from MDS (P = .001). Five-year probability of relapse was 9%, 22%, 24%, 56%, and 53%, respectively (P < .001). Five-year transplant-related mortality (TRM) was 14%, 39%, 38%, 34%, and 44%, respectively (P = .24). In multivariate analysis, WHO classification showed a significant effect on OS (P = .017) and probability of relapse (P = .01); transfusion dependency was associated with a reduced OS (P = .01) and increased TRM (P = .037), whereas WPSS showed a prognostic significance on both OS (P = .001) and probability of relapse (P < .001). In patients without excess blasts, multilineage dysplasia and transfusion dependency affected OS (P = .001 and P = .009, respectively), and were associated with an increased TRM (P = .013 and P = .031, respectively). In these patients, WPSS identified 2 groups with different OS and TRM. These data suggest that WHO classification and WPSS have a relevant prognostic value in posttransplantation outcome of MDS patients.
|Autori:||Alessandrino EP; Della Porta MG; Bacigalupo A; Van Lint MT; Falda M; Onida F; Bernardi M; Iori AP; Rambaldi A; Cerretti R; Marenco P; Pioltelli P; Malcovati L; Pascutto C; Oneto R; Fanin R; Bosi A; Gruppo Italiano Trapianto di Midollo Osseo (GITMO); Levis A; Rambaldi A; Bandini G; Casini M; Rossi G; Angelucci E; Baronciani D; La Nasa G; Milone G; Mordini N; Guidi S; Bosi A; Bacigalupo A; Van Lint MT; Corradini P; Milani R; Morra E; Marenco P; Lambretenghi Deliliers G; Onida F; Ciceri F; Bernardi M; Castagna L; Narni F; Pioltelli P; Selleri C; Scimè R; Iannitto E; Musso M; Alessandrino EP; Locatelli F; Martelli F; Visani G; Di Bartolomeo P; Cavanna L; Papineschi F; Messina G; Gugliotta L; Iori AP; Foà R; Locasciulli A; Majolino I; Chiusolo P; Leone G; Arcese W; Cerretti R; Carella AM; Cascavilla N; Mazza P; Falda M; Bruno B; Boccadoro M; Fanin R; Cerno M; Raimondi R.|
|Titolo:||WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)|
|Anno del prodotto:||2008|
|Appare nelle tipologie:||1.1 Articolo in rivista|