Degeneration and Regeneration in the Vertebrate Retina

1. Introduction 2. Retinal diseases 2.1 Retinitis pigmentosa 2.2 Age-related macular degeneration 3. Animal models for retinopathies 3.1 Mouse models for retina degeneration 3.1.1 Mouse models for RP: mutations in rhodopsin 3.1.2 Mouse models for RP: mutations affecting phototransduction pathway 3.1.3 Mouse models for RP: mutations affecting photoreceptor structural proteins 3.1.4 Mouse models for RP: mutations affecting ciliary proteins 3.1.5 Mouse models for age-related macular degeneration 3.1.6 Mouse models and therapies for retina degeneration 3.2 Alternative models for retina degeneration 4. Studying retina regeneration in vivo 4.1 Transgenic models for regeneration studies 4.2 Sources of regeneration 4.2.1 CMZ and RPE as a source of retina regeneration 4.2.2 Müller glia as a source of retina regeneration 4.3 Candidate genes and signaling pathways involved in regeneration 4.3.1 Transcription factors promoting regeneration 4.3.2 Signaling molecules involved in regeneration 5. Conclusion