An unprecedented green methodology is described for the preparation of differently substituted indoles via microwave-assisted cycloisomerization of 2-alkynylaniline derivatives in water. Moderate to good yields in the cyclization can be achieved for a variety of 2-aminoaryl alkynes. Reactions are run without any added metal catalyst, acid, or base, and do not take place by applying conventional heating.
|Autori:||CARPITA A; RIBECAI A|
|Titolo:||Microwave-assisted synthesis of indole-derivatives via cycloisomerization of 2-alkynylanilines in water without added catalysts, acids, or bases|
|Anno del prodotto:||2009|
|Digital Object Identifier (DOI):||10.1016/j.tetlet.2009.09.135|
|Appare nelle tipologie:||1.1 Articolo in rivista|