The effectiveness of enilconazole (4 weekly rinses with a 0.2% solution) or griseofulvin (50 mg/kg twice daily for 40 days) following a pre-treatment with oral lufenuron (100 mg/kg by-weekly for 8 weeks) was tested on 25 (11 + 14) Microsporum canis infected cats. Control animals were treated with lufenuron, griseofulvin and enilconazole alone. At day 150 pre-treated animals were culturally negative and clinically cured. While lufenuron alone was found to be ineffective against M canis infection, an immunomodulatory effect of the drug can be suggested, as reported in literature. Its use could be reserved to long-lasting infections, unsuccessfully treated with conventional drugs. Further Studies are required to clearly establish the possible adjuvant effect of this molecule when used prior to enilconazole or griseofulvin. (C) 2008 ESFM and AAFP. Published by Elsevier Ltd. All rights reserved.
|Autori:||Mancianti F; Dabizzi Sara; Nardoni Simona|
|Titolo:||A lufenuron pre-treatment may enhance the effects of enilconazole or griseofulvin in feline dermatophytosis?|
|Anno del prodotto:||2009|
|Digital Object Identifier (DOI):||10.1016/j.jfms.2008.05.006|
|Appare nelle tipologie:||1.1 Articolo in rivista|