Chemicals that can inhibit other sensible point of purine biosynthesis than inosine monophosphate dehydrogenase are considered as potential antiviral drugs. Among them, mercaptopurine and its derivates are immunosuppressive drugs widely used in medical therapy, which mechanism of action can be partially associated to inhibition of purine biosynthesis. Aim of this research is a preliminary study regarding the antiviral action of 2-amino-6-mercaptopurine against Grapevine Leafroll-associated virus-1 and -3 in grapevine plants. The drugs seems to be effective on virus replication but any eradication of virus was registered. These findings suggest further steps of treatments and/or higher dosage of drug, making mercaptopurines interesting as group of chemicals for searching novel antiviral drugs for grapevine chemotherapy.
2-AMINO-6-Mercaptopurine: a preliminary study of a novel chemical group for grapevine antiviral therapy
PANATTONI, ALESSANDRA;TRIOLO, ENRICO
2009-01-01
Abstract
Chemicals that can inhibit other sensible point of purine biosynthesis than inosine monophosphate dehydrogenase are considered as potential antiviral drugs. Among them, mercaptopurine and its derivates are immunosuppressive drugs widely used in medical therapy, which mechanism of action can be partially associated to inhibition of purine biosynthesis. Aim of this research is a preliminary study regarding the antiviral action of 2-amino-6-mercaptopurine against Grapevine Leafroll-associated virus-1 and -3 in grapevine plants. The drugs seems to be effective on virus replication but any eradication of virus was registered. These findings suggest further steps of treatments and/or higher dosage of drug, making mercaptopurines interesting as group of chemicals for searching novel antiviral drugs for grapevine chemotherapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
