A straightforward methodology is described for the copper- and solvent-free alkynylations of aryl iodides and bromides using 0.1–0.01 mol % of Pd as Pd EnCatTM 40 or TPP30. High yielding reactions can be achieved under aerobic conditions for a variety of activated and deactivated aryl iodides; a few examples with aryl bromides are also described. Microwave irradiation is able to enhance yields and rates of these reactions.
|Autori interni:||CARPITA, ADRIANO|
|Autori:||CARPITA A; RIBECAI A|
|Titolo:||Convenient copper- and solvent-free Sonogashira-type alkynilation of aryl iodides and bromides using Pd EncatTM|
|Anno del prodotto:||2009|
|Digital Object Identifier (DOI):||10.1016/j.tetlet.2008.10.130|
|Appare nelle tipologie:||1.1 Articolo in rivista|