A straightforward methodology is described for the copper- and solvent-free alkynylations of aryl iodides and bromides using 0.1–0.01 mol % of Pd as Pd EnCatTM 40 or TPP30. High yielding reactions can be achieved under aerobic conditions for a variety of activated and deactivated aryl iodides; a few examples with aryl bromides are also described. Microwave irradiation is able to enhance yields and rates of these reactions.
Convenient copper- and solvent-free Sonogashira-type alkynilation of aryl iodides and bromides using Pd EncatTM
CARPITA, ADRIANO;
2009-01-01
Abstract
A straightforward methodology is described for the copper- and solvent-free alkynylations of aryl iodides and bromides using 0.1–0.01 mol % of Pd as Pd EnCatTM 40 or TPP30. High yielding reactions can be achieved under aerobic conditions for a variety of activated and deactivated aryl iodides; a few examples with aryl bromides are also described. Microwave irradiation is able to enhance yields and rates of these reactions.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
