Background: Osteopontin is an extracellular matrix cytokine which promotes inflammation and vascular remodeling in atherosclerosis. On the other hand hypertension is known to be a major risk factor for atherosclerosis and cardiovascular disease. Purpose of the study was to assess the relationships of osteopontin with indexes of clinical severity and organ damage in hypertensive patients. Methods: We measured plasma osteopontin levels (Assay Designs Inc, Ann Arbor Mi, US) in 133 consecutive patients (74F, 59M, men age 57±14SD yrs), who undewent a diagnostic evaluation for arterial hypertension in the Cardiovascular Day Hospital Department. In each patient blood pressure levels, endocrine and metabolic parameters and cardiovascular pathology were investigated by standardized examinations. Student t-test and multiple regression analysis were used for stastistical evaluation. Results: Out of the 133 patients osteopontin levels (mean 28.32±17.68 ng/ml) were significantly higher in those with more relevant disease, grouped according to the median values of serum creatinine, blood pressure levels, left ventricular wall thickness and the Doppler index of renal vascular resistances respectively (all p<0.01). Osteopontin was also associated with the presence of carotid atherosclerotic plaques (p<0.01) and diabetes (p<0.01). On multiple regression analysis osteopontin was found to be significantly related to serum creatinine, diastolic blood pressure, left ventricular wall thickness (all p<0.01) and N-terminal proBNP levels (p<0.05). Conclusions: Osteopontin appears to be associated with many indexes of clinical severity and organ damage in arterial hypertension, suggesting its role in the disease as a marker of vascular inflammation and remodeling with a possible prognostic significance.
Osteopontin is related to clinical severity and organ damage in arterial hypertension: an observational study in 133 patients
FOMMEI, ENZA;
2009-01-01
Abstract
Background: Osteopontin is an extracellular matrix cytokine which promotes inflammation and vascular remodeling in atherosclerosis. On the other hand hypertension is known to be a major risk factor for atherosclerosis and cardiovascular disease. Purpose of the study was to assess the relationships of osteopontin with indexes of clinical severity and organ damage in hypertensive patients. Methods: We measured plasma osteopontin levels (Assay Designs Inc, Ann Arbor Mi, US) in 133 consecutive patients (74F, 59M, men age 57±14SD yrs), who undewent a diagnostic evaluation for arterial hypertension in the Cardiovascular Day Hospital Department. In each patient blood pressure levels, endocrine and metabolic parameters and cardiovascular pathology were investigated by standardized examinations. Student t-test and multiple regression analysis were used for stastistical evaluation. Results: Out of the 133 patients osteopontin levels (mean 28.32±17.68 ng/ml) were significantly higher in those with more relevant disease, grouped according to the median values of serum creatinine, blood pressure levels, left ventricular wall thickness and the Doppler index of renal vascular resistances respectively (all p<0.01). Osteopontin was also associated with the presence of carotid atherosclerotic plaques (p<0.01) and diabetes (p<0.01). On multiple regression analysis osteopontin was found to be significantly related to serum creatinine, diastolic blood pressure, left ventricular wall thickness (all p<0.01) and N-terminal proBNP levels (p<0.05). Conclusions: Osteopontin appears to be associated with many indexes of clinical severity and organ damage in arterial hypertension, suggesting its role in the disease as a marker of vascular inflammation and remodeling with a possible prognostic significance.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
